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Article

Singlet molecular oxygen induced mutagenicity in a mammalian SV40-based shuttle vector.

Photochemistry and photobiology - 1 Mar 1990

Di Mascio P, Menck C F, Nigro R G, Sarasin A, Sies H

Abstract excerpt

We have determined the deleterious effects of singlet oxygen (1O2), generated by thermal decomposition of the water-soluble endoperoxide 3,3'-(1,4-naphthylidene)dipropionate (NDPO2), on plasmid DNA. By following the electrophoretic mobility of DNA on agarose gels, we detected single and double strand breaks induced by treatment with NDPO2. The vector employed was a mammalian shuttle vector and the mutagenic...

Topics

Animals
Cell Line
Escherichia coli
Genetic Vectors
Mutation
Oxygen
Photochemistry
Plasmids
Restriction Mapping
Simian virus 40
Singlet Oxygen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2162544
DOI: 10.1111/j.1751-1097.1990.tb01713.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2162544-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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