Mutations induced by monofunctional and bifunctional phosphoramide mustards in supF tRNA gene.

doi:10.1016/s0027-5107(97)00147-4

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Article

Mutations induced by monofunctional and bifunctional phosphoramide mustards in supF tRNA gene.

Mutation research - 19 Nov 1997

Mudipalli A, Maccubbin A E, Nadadur S S, Struck R F, Gurtoo H L

Abstract excerpt

The relative mutagenicity, nature of the mutations and the sequence specificity of mutations induced by the bifunctional alkylating agent, phosphoramide mustard (PM) and a monofunctional derivative, dechloroethyl phosphoramide mustard (dePM), were analyzed by the Ames test and by an in vitro shut...

Topics

Alkylating Agents
Base Sequence
Cell Line
Genes, Suppressor
Humans
Molecular Sequence Data
Mutagenicity Tests
Mutagens
Mutation
Phosphoramide Mustards
Plasmids
RNA, Transfer
Structure-Activity Relationship

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