Article
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Human mutation - 1 Feb 2005
Jiang Zhengwen, Dalton Timothy P, Jin Li, Wang Bin, Tsuneoka Yutaka, Shertzer Howard G, Deka Ranjan, Nebert Daniel W
Abstract excerpt
Interindividual differences in human CYP1A1 and CYP1A2 expression appear to be associated with variability in risk toward various types of environmental toxicity and cancer. These two genes are oriented head-to-head on human chromosome 15; the 23.3-kb spacer region might contain distinct regulatory regions for CYP1A1 and distinct regulatory regions for CYP1A2, or the regulatory regions for the two genes might...
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