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Article

Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.

Circulation. Cardiovascular genetics - 1 Feb 2015

Mopidevi Brahmaraju, Kaw Meenakshi K, Puri Nitin, Ponnala Madhusudan, Jain Sudhir, Rana Anita, Keetha Narsimha R, Khuder Sadik A, Fiering Steven N, Kumar Ashok

Abstract excerpt

BACKGROUND: Aldosterone, synthesized in the adrenal cortex by the enzyme CYP11B2, induces positive sodium balance and predisposes to hypertension. Various investigators, using genomic DNA analyses, have linked -344T polymorphism in the human CYP11B2 (hCYP11B2) gene to human hypertension. hCYP11B2 gene promoter has 3 single-nucleotide polymorphisms in linkage disequilibrium: T/A at -663, T/C at -470, and C/T at...

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Share to Cytochrome P-450 CYP11B2
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Sodium Chloride, Dietary

Source

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Identifiers

PMID: 25504670
DOI: 10.1161/CIRCGENETICS.114.000694
PMCID: PMC4334713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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