Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.

doi:10.1016/j.bbrc.2007.05.202

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Article

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.

Biochemical and biophysical research communications - 3 Aug 2007

Dragin Nadine, Uno Shigeyuki, Wang Bin, Dalton Timothy P, Nebert Daniel W

Abstract excerpt

Human/rodent CYP1A1 and CYP1A2 orthologs are well known to exhibit species-specific differences in substrate preferences and rates of metabolism. This lab previously characterized a BAC-transgenic mouse carrying the human CYP1A1_CYP1A2 locus; in this line, human dioxin-inducible CYP1A1 and basal vs dioxin-inducible CYP1A2 have been shown to be expressed normally (with regard to mRNAs, proteins and three enzyme...

Topics

Animals
Benzo(a)pyrene
Cell Culture Techniques
Cell Separation
Cells, Cultured
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP1A2
Gene Expression Regulation
Genotype
Humans
Intestinal Mucosa
Liver
Mice
Mice, Knockout
RNA, Messenger

Source

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Identifiers

PMID: 17560947
DOI: 10.1016/j.bbrc.2007.05.202
PMCID: PMC1994648

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