Article
Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance.
Pharmacogenetics - 1 Nov 2000
Aitchison K J, Gonzalez F J, Quattrochi L C, Sapone A, Zhao J H, Zaher H, Elizondo G, Bryant C, Munro J, Collier D A, Makoffa A I, Kerwin R W
Abstract excerpt
CYP1A2 activity has been demonstrated to be bimodally or trimodally distributed in several populations, consistent with a codominant or recessive functional genetic polymorphism. However, studies aimed at identifying polymorphisms in CYPIA2 have not yet adequately accounted for this distribution pattern. To search for functional polymorphisms, we performed genome-walking, polymerase chain reaction (PCR)...
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