Article
Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.
Environmental health perspectives - 1 Jul 1998
Maier A, Micka J, Miller K, Denko T, Chang C Y, Nebert D W, Alvaro Puga
Abstract excerpt
Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach for the rapid identification of DNA sequence differences between Ahr alleles. Oligonucleotides...
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