Article
Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2.
Carcinogenesis - 1 Nov 2011
Dobbernack Gisela, Meinl Walter, Schade Nicole, Florian Simone, Wend Korinna, Voigt Ingo, Himmelbauer Heinz, Gross Madeleine, Liehr Thomas, Glatt Hansruedi
Abstract excerpt
Soluble sulfotransferases (SULTs) generate electrophilically reactive metabolites from numerous food-borne compounds, environmental contaminants and drugs, often resulting in mutagenicity and carcinogenicity. Substrate specificity, regulation and tissue distribution of SULTs show large interspecies differences. In humans, therefore, SULTs may be involved in the induction of cancer in different tissues than in...
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