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Article

A haplotype of angiotensin receptor type 1 associated with human hypertension increases blood pressure in transgenic mice.

The Journal of biological chemistry - 27 Dec 2013

Jain Sudhir, Prater Alicia, Pandey Varunkumar, Rana Anita, Puri Nitin, Kumar Ashok

Abstract excerpt

The renin-angiotensin system plays an important role in the regulation of blood pressure via angiotensin II and the angiotensin II receptor type 1 (AT1R). Human AT1R gene promoter has four SNPs: T/A at -777, T/G at -680, A/C at -214, and A/G at -119, that are in linkage disequilibrium. Variants -777T, -680T, -214A, and -119A almost always occur together (named haplotype I), and variants -777A, -680G, -214C, and...

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Identifiers

PMID: 24202179
DOI: 10.1074/jbc.M113.520023
PMCID: PMC3873561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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