Article
Suppression of transformed phenotype in hybrids of v-fgr and v-raf transformed rat-1 cells with rat embryonic fibroblasts is due to transcriptional inactivation of viral oncogenes.
Experimental cell research - 1 May 1992
Martin W, Lenz E, Grohé B, Willecke K
Abstract excerpt
Rat-1 cells that had been transformed to tumorigenicity by transfection with the retroviral oncogenes v-raf from 3611-murine sarcoma virus, or v-fgr from Gardner-Rasheed feline sarcoma virus were fused with rat embryonic fibroblasts at an early passage. In both fusion experiments hybrid cells wer...
Topics
- Animals
- Cell Line, Transformed
- Fibroblasts
- Gene Expression Regulation, Viral
- Genes, Viral
- Hybrid Cells
- Oncogenes
- Phenotype
- Rats
- Repetitive Sequences, Nucleic Acid
- Transcription, Genetic