Rat primary embryo fibroblast cells suppress transformation by the E6 and E7 genes of human papillomavirus type 16 in somatic hybrid cells.

doi:10.1128/JVI.65.1.479-482.1991

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Article

Rat primary embryo fibroblast cells suppress transformation by the E6 and E7 genes of human papillomavirus type 16 in somatic hybrid cells.

Journal of virology - 1 Jan 1991

Miyasaka M, Takami Y, Inoue H, Hakura A

Abstract excerpt

The E6 and E7 genes of human papillomavirus type 16 (HPV-16) transform established lines of rat cells but not rat cells in primary culture irrespective of the expression of the two genes. The reason for this difference between the susceptibilities of cell lines and primary cells was examined by using hybrid cells obtained by somatic cell fusion of rat cell lines transformed by the E6 and E7 genes of HPV-16 and...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
DNA
DNA, Viral
Embryo, Mammalian
Fibroblasts
Genes, Viral
Humans
Hybrid Cells
Open Reading Frames

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papillomaviridae

Phenotype

RNA

RNA, Messenger

Rats

Suppression, Genetic

Source

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Identifiers

PMID: 1702162
DOI: 10.1128/JVI.65.1.479-482.1991
PMCID: PMC240542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702162-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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