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Article

Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.

Oncogene - 2 Nov 1995

Xu L, Meng Y, Wallen R, DePinho R A

Abstract excerpt

The modulation of RNA polymerase II processivity through the untranslated N-myc first exon represents an important mechanism governing N-myc mRNA levels during normal development. In this study, we employed the rat embryo fibroblast (REF) cooperation assay as a functional means to (i) map N-myc first exon sequences involved in the regulation of N-myc gene expression and specifically their contribution to...

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PMID: 7478616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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