Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.

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Article

Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.

Oncogene - 2 Nov 1995

Xu L, Meng Y, Wallen R, DePinho R A

Abstract excerpt

The modulation of RNA polymerase II processivity through the untranslated N-myc first exon represents an important mechanism governing N-myc mRNA levels during normal development. In this study, we employed the rat embryo fibroblast (REF) cooperation assay as a functional means to (i) map N-myc first exon sequences involved in the regulation of N-myc gene expression and specifically their contribution to...

Topics

Animals
Avian Sarcoma Viruses
Base Sequence
Binding Sites
Cell Nucleus
Cell Transformation, Neoplastic
Embryo, Mammalian
Exons
Fibroblasts
Gene Expression
Genes, myc
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Phenotype

Proto-Oncogene Proteins c-myc

RNA Polymerase II

Rats

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 7478616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478616-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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