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Article

Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In Vitro

1 Jan 2005

Abstract excerpt

The telomeric single-strand DNA binding protein protection of telomeres 1 (POT1) protects telomeres from rapid degradation in Schizosaccharomyces pombe and has been implicated in positive and negative telomere length regulation in humans. Human POT1 appears to interact with telomeres both through direct binding to the 3' overhanging G-strand DNA and through interaction with the TRF1 duplex telomere DNA binding...

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Identifiers

PMID: 15632080
DOI: 10.1128/mcb.25.2.808-818.2005

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Related research

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Research trail→

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Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In VitroPMID 15632080Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

Human POT1 Facilitates Telomere Elongation by TelomeraseSemantic proximity Read ↗

Role of POT1 in Human CancerSemantic proximity Read ↗

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.Semantic proximity Read ↗

Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.Semantic proximity Read ↗

Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability.Semantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

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