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Article

Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability.

Molecular and cellular biology - 1 Jul 2005

Bunch Jeremy T, Bae Nancy S, Leonardi Jessica, Baumann Peter

Abstract excerpt

The fission yeast Pot1 (protection of telomeres) protein binds to the single-stranded extensions at the ends of telomeres, where its presence is critical for the maintenance of linear chromosomes. Homologs of Pot1 have been identified in a wide variety of eukaryotes, including plants, animals, and humans. We now show that Pot1 plays dual roles in telomere length regulation and chromosome end protection. Using a...

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Share to Chromosomal Instability
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Protein Structure, Tertiary

Share to Sequence Homology, Amino Acid

Share to Telomerase

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Share to Telomere-Binding Proteins

Source

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Identifiers

PMID: 15964812
DOI: 10.1128/MCB.25.13.5567-5578.2005
PMCID: PMC1156986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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