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POT1 and TRF2 Cooperate To Maintain Telomeric Integrity

18 Jan 2005

Abstract excerpt

Mammalian telomeric DNA contains duplex TTAGGG repeats and single-stranded overhangs. POT1 (protection of telomeres 1) is a telomere-specific single-stranded DNA-binding protein, highly conserved in eukaryotes. The biological function of human POT1 is not well understood. In the present study, we demonstrate that POT1 plays a key role in telomeric end protection. The reduction of POT1 by RNA interference led to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15657433
DOI: 10.1128/mcb.25.3.1070-1080.2005

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

POT1 and TRF2 Cooperate To Maintain Telomeric IntegrityPMID 15657433Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In VitroSemantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability.Semantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.Semantic proximity Read ↗

Human POT1 Facilitates Telomere Elongation by TelomeraseSemantic proximity Read ↗

Role of POT1 in Human CancerSemantic proximity Read ↗

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.Semantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

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