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Article

POT1 Association with TRF2 Regulates Telomere Length

3 Aug 2009

Abstract excerpt

Deleting the OB folds encoding the telomeric single-stranded DNA (ssDNA)-binding activity of the human telomeric protein POT1 induces significant telomere elongation, suggesting that at least one critical aspect of the regulation of telomere length is disrupted by this POT1(DeltaOB) mutant protein. POT1 is known to associate with two proteins through the protein interaction domain retained in POT1(DeltaOB)-the...

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19651898
DOI: 10.1128/mcb.00286-09

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Related research

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Research trail→

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POT1 Association with TRF2 Regulates Telomere LengthPMID 19651898Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.Semantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length RegulationSemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

TIN2 functions with TPP1/POT1 to stimulate telomerase processivitySemantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

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