Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.

Neuron - 6 Jan 2005

Zhang Xiaodong, Gainetdinov Raul R, Beaulieu Jean-Martin, Sotnikova Tatyana D, Burch Lauranell H, Williams Redford B, Schwartz David A, Krishnan K Ranga R, Caron Marc G

Abstract excerpt

Dysregulation of central serotonin neurotransmission has been widely suspected as an important contributor to major depression. Here, we identify a (G1463A) single nucleotide polymorphism (SNP) in the rate-limiting enzyme of neuronal serotonin synthesis, human tryptophan hydroxylase-2 (hTPH2). Th...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Arginine
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Histidine

Share to PC12 Cells

Share to Serotonin

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 15629698
DOI: 10.1016/j.neuron.2004.12.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15629698-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.PMID 15629698Read ↗

A functional alternative splicing mutation in human tryptophan hydroxylase-2.Semantic proximity Read ↗

Functional properties of missense variants of human tryptophan hydroxylase 2Semantic proximity Read ↗

In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.Semantic proximity Read ↗

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.Semantic proximity Read ↗

Targeting tryptophan hydroxylase 2 in affective disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.