Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2.

Journal of neurochemistry - 1 Mar 2007

Winge Ingeborg, McKinney Jeffrey A, Knappskog Per M, Haavik Jan

Abstract excerpt

Tryptophan hydroxylase (TPH) catalyses the rate-limiting step in the biosynthesis of serotonin. In vertebrates, the homologous genes tph1 and tph2 encode two different enzymes with distinct patterns of expression, enzyme kinetics and regulation. Variants of TPH2 have recently reported to be associated with reduced serotonin production and behavioural alterations in man and mice. We have produced the human forms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Cell Line, Transformed
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Gene Expression Regulation, Enzymologic

Share to Models, Molecular

Share to Tryptophan

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 17181551
DOI: 10.1111/j.1471-4159.2006.04290.x

Genes

TPH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2.PMID 17181551Read ↗

Functional properties of missense variants of human tryptophan hydroxylase 2Semantic proximity Read ↗

Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization.Semantic proximity Read ↗

Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.Semantic proximity Read ↗

In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.Semantic proximity Read ↗

A functional alternative splicing mutation in human tryptophan hydroxylase-2.Semantic proximity Read ↗

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.Semantic proximity Read ↗

Structural characterization of human tryptophan hydroxylase 2 reveals L-Phe as the superior regulatory domain ligand relevant for serotonin biosynthesisSemantic proximity Read ↗

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity.Semantic proximity Read ↗

Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling.Semantic proximity Read ↗

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.