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Article

In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.

PloS one - 1 Jan 2020

Pereira Gabriel Rodrigues Coutinho, Tavares Gustavo Duarte Bocayuva, de Freitas Marta Costa, De Mesquita Joelma Freire

Abstract excerpt

The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin is known for its role in several homeostatic systems related to sleep, mood, and food intake. As the reaction catalyzed by TPH2 is the rate-limiting step of serotonin biosynthesis, mutations in TPH2 have been associated with several psychiatric disorders (PD). This work undertakes an in silico analysis of the...

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Identifiers

PMID: 32119710
DOI: 10.1371/journal.pone.0229730
PMCID: PMC7051086

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