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Article

Functional properties of missense variants of human tryptophan hydroxylase 2

24 Mar 2009

Abstract excerpt

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Several variants of human TPH2 have been reported to be associated with a spectrum of neuropsychiatric disorders such as unipolar major depression, bipolar disorder, suicidality, and attention-deficit/hyperactivity disorder (ADHD). We used three different expression systems: rabbit reticulocyte...

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PMID: 19319927
DOI: 10.1002/humu.20956

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