Article
No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects.
Biological psychiatry - 15 Jul 2006
Delorme Richard, Durand Christelle M, Betancur Catalina, Wagner Michael, Ruhrmann Stephan, Grabe Hans-Juergen, Nygren Gudrun, Gillberg Christopher, Leboyer Marion, Bourgeron Thomas, Courtet Philippe, Jollant Fabrice, Buresi Catherine, Aubry Jean-Michel, Baud Patrick, Bondolfi Guido, Bertschy Gilles, Perroud Nader, Malafosse Alain
Abstract excerpt
BACKGROUND: It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects). METHODS: We explored the occurrence of this variation in patients with affective disorders (n = 646), autism spectrum disorders...
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