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Article

Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

Journal of neurochemistry - 1 Sept 2014

Carkaci-Salli Nurgul, Salli Ugur, Tekin Izel, Hengst Jeremy A, Zhao Moe K, Gilman T Lee, Andrews Anne M, Vrana Kent E

Abstract excerpt

Human TPH2 (hTPH2) catalyzes the rate-limiting step in CNS serotonin biosynthesis. We characterized a single-nucleotide polymorphism (C2755A) in the hTPH2 gene that substitutes tyrosine for serine at position 41 in the regulatory domain of the enzyme. This polymorphism is associated with bipolar disorder and peripartum depression in a Chinese population. Recombinant h TPH2 human proteins were expressed in...

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Identifiers

PMID: 24899127
DOI: 10.1111/jnc.12779
PMCID: PMC7336366

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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