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Article

Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.

Molecular psychiatry - 1 Jul 2010

Kloiber S, Kohli M A, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld P G, Horstmann S, Salyakina D, Muller-Myhsok B, Binder E B, Holsboer F, Lucae S

Abstract excerpt

Major depression and the metabolic syndrome (MetS) are interacting clinical conditions influenced by genetic susceptibility. For both disorders, impaired serotonergic neurotransmission in specific brain areas has been suggested. This led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (TPH2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be...

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Source

Identifiers

PMID: 19125159
DOI: 10.1038/mp.2008.142

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.PMID 19125159Read ↗

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