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Article

Loss of hPot1 function leads to telomere instability and a cut-like phenotype.

Current biology : CB - 29 Dec 2004

Veldman Timothy, Etheridge Katherine T, Counter Christopher M

Abstract excerpt

The human telomere binding protein hPot1 binds to the most distal single-stranded extension of telomeric DNA in vitro, and probably in vivo, as well as associating with the double-stranded telomeric DNA binding proteins TRF1 and TRF2 through the bridging proteins PTOP (also known as PIP1 or TINT1) and TIN2. Disrupting either the DNA binding activity of hPot1 or its association with PTOP results in elongated...

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Share to Chromosomal Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15620654
DOI: 10.1016/j.cub.2004.12.031

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of hPot1 function leads to telomere instability and a cut-like phenotype.PMID 15620654Read ↗

Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

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Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA RepairSemantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endSemantic proximity Read ↗

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Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.Semantic proximity Read ↗

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.Semantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

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POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

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