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Article

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.

Molecular and cellular biology - 1 Apr 2004

Armbruster Blaine N, Linardic Corinne M, Veldman Tim, Bansal Niharika P, Downie Diane L, Counter Christopher M

Abstract excerpt

The protein hPot1 shares homology with telomere-binding proteins in lower eukaryotes and associates with single-stranded telomeric DNA in vitro as well as colocalizing with telomere-binding proteins in vivo. We now show that hPot1 is coimmunoprecipitated with telomeric DNA and that stable express...

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Identifiers

PMID: 15060173
DOI: 10.1128/MCB.24.8.3552-3561.2004
PMCID: PMC381596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15060173-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.PMID 15060173Read ↗

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Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTRSemantic proximity Read ↗

Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA RepairSemantic proximity Read ↗

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.Semantic proximity Read ↗

The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifsSemantic proximity Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNASemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

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