Article
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science (New York, N.Y.) - 11 May 2001
Baumann P, Cech T R
Abstract excerpt
Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and in humans. These Pot1 (protection of telomeres) proteins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends. Deletion of the fission yeast...
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