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Article

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.

Oncogene - 6 Apr 2017

Gu P, Wang Y, Bisht K K, Wu L, Kukova L, Smith E M, Xiao Y, Bailey S M, Lei M, Nandakumar J, Chang S

Abstract excerpt

Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing the activation of aberrant DNA damage and repair responses at telomeres. Sporadic and familial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27869160
DOI: 10.1038/onc.2016.405
PMCID: PMC5383532

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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