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Article

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.

Nature - 13 Dec 2012

Nandakumar Jayakrishnan, Bell Caitlin F, Weidenfeld Ina, Zaug Arthur J, Leinwand Leslie A, Cech Thomas R

Abstract excerpt

Human chromosome ends are capped by shelterin, a protein complex that protects the natural ends from being recognized as sites of DNA damage and also regulates the telomere-replicating enzyme, telomerase. Shelterin includes the heterodimeric POT1-TPP1 protein, which binds the telomeric single-stranded DNA tail. TPP1 has been implicated both in recruiting telomerase to telomeres and in stimulating telomerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23103865
DOI: 10.1038/nature11648
PMCID: PMC3521872

Genes

TPP1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.PMID 23103865Read ↗

Identification of human TERT elements necessary for telomerase recruitment to telomeres.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

Structural and functional consequences of a disease mutation in the telomere protein TPP1.Semantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.Semantic proximity Read ↗

Characterization of novel mutations in the TEL-patch domain of the telomeric factor TPP1 associated with telomere biology disorders.Semantic proximity Read ↗

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase ActionSemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.Semantic proximity Read ↗

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