Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTOP interacts with POT1 and regulates its localization to telomeres.

Nature cell biology - 1 Jul 2004

Liu Dan, Safari Amin, O'Connor Matthew S, Chan Doug W, Laegeler Andrew, Qin Jun, Songyang Zhou

Abstract excerpt

Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12). POT1 belongs to a family of oligonucleotide-binding (OB)-fold-containing proteins that include Oxytricha nova TEBP, Cdc13, and spPot1, which specifically recognize telomeric single-stranded DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to DNA, Single-Stranded

Share to RNA Interference

Share to Shelterin Complex

Share to Telomere

Share to Telomere-Binding Proteins

Source

Identifiers

PMID: 15181449
DOI: 10.1038/ncb1142

Genes

POT1
PINX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTOP interacts with POT1 and regulates its localization to telomeres.PMID 15181449Read ↗

POT1 Association with TRF2 Regulates Telomere LengthSemantic proximity Read ↗

The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifsSemantic proximity Read ↗

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length RegulationSemantic proximity Read ↗

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.Semantic proximity Read ↗

Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Semantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeresSemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.