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Article

Specificity and function of archaeal DNA replication initiator proteins.

Cell reports - 21 Feb 2013

Samson Rachel Y, Xu Yanqun, Gadelha Catarina, Stone Todd A, Faqiri Jamal N, Li Dongfang, Qin Nan, Pu Fei, Liang Yun Xiang, She Qunxin, Bell Stephen D

Abstract excerpt

Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the archaeon Sulfolobus islandicus are specified by distinct initiation factors. While two origins...

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Identifiers

PMID: 23375370
DOI: 10.1016/j.celrep.2013.01.002
PMCID: PMC3607249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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