Article
Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.
Cancer research - 15 Apr 1992
Felix C A, Kappel C C, Mitsudomi T, Nau M M, Tsokos M, Crouch G D, Nisen P D, Winick N J, Helman L J
Abstract excerpt
The p53 gene was examined in primary or metastatic tumors from six patients with rhabdomyosarcoma (RMS) and in five RMS cell lines by screening methods including single-strand conformation polymorphism analysis, the RNase protection assay, sequencing of complementary DNA subclones, and Southern blotting. Six original tumors were of embryonal histology, four alveolar, and one mixed. p53 mutations were identified...
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