Article
Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.
Cancer research - 15 Apr 1992
Felix C A, Kappel C C, Mitsudomi T, Nau M M, Tsokos M, Crouch G D, Nisen P D, Winick N J, Helman L J
Abstract excerpt
The p53 gene was examined in primary or metastatic tumors from six patients with rhabdomyosarcoma (RMS) and in five RMS cell lines by screening methods including single-strand conformation polymorphism analysis, the RNase protection assay, sequencing of complementary DNA subclones, and Southern b...
Topics
- Adolescent
- Adult
- Base Sequence
- Child
- Child, Preschool
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Gene Frequency
- Genes, p53
- Humans
- Infant
- Molecular Sequence Data
- Mutation
- Rhabdomyosarcoma
- Tumor Cells, Cultured