Article
Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood.
Blood - 15 Nov 1993
Wada M, Bartram C R, Nakamura H, Hachiya M, Chen D L, Borenstein J, Miller C W, Ludwig L, Hansen-Hagge T E, Ludwig W D
Abstract excerpt
p53 mutations are found in a wide variety of cancers, including hematologic malignancies. These alterations apparently contribute to development of the malignant phenotype. We analyzed a large series of lymphoid (330 cases) and a smaller series of myeloid (29 cases) malignancies of childhood for p53 mutations by single-strand conformational polymorphism (SSCP) following polymerase chain reaction. Samples with...
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