Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood.

Article

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood.

Blood - 15 Nov 1993

Wada M, Bartram C R, Nakamura H, Hachiya M, Chen D L, Borenstein J, Miller C W, Ludwig L, Hansen-Hagge T E, Ludwig W D

Abstract excerpt

p53 mutations are found in a wide variety of cancers, including hematologic malignancies. These alterations apparently contribute to development of the malignant phenotype. We analyzed a large series of lymphoid (330 cases) and a smaller series of myeloid (29 cases) malignancies of childhood for...

Topics

Adolescent
Base Sequence
Child
Child, Preschool
Female
Genes, p53
Humans
Leukemia
Lymphoma
Male
Molecular Sequence Data
Mutation

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