Article
Mutations of the p53 gene in malignant rhabdoid tumors of soft tissue and the kidney: immunohistochemical and DNA direct sequencing analysis.
Journal of cancer research and clinical oncology - 1 Jan 2001
Kinoshita Y, Shiratsuchi H, Tamiya S, Oshiro Y, Hachitanda Y, Oda Y, Suita S, Tsuneyoshi M
Abstract excerpt
Malignant rhabdoid tumor (MRT) is characterized by the presence of intracytoplasmic eosinophilic inclusions composed of whorls of intermediate filaments. This tumor was originally described as an entity of the abortive type of Wilms' tumor in childhood. Recently, it has been proved that these rhabdoid cells can be observed in various types of malignant tumors, including soft tissue sarcoma or carcinoma. To...
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