Mechanisms of p53 loss in human sarcomas.

doi:10.1073/pnas.87.15.5863

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Article

Mechanisms of p53 loss in human sarcomas.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Mulligan L M, Matlashewski G J, Scrable H J, Cavenee W K

Abstract excerpt

An important role for the p53 gene in neoplastic transformation in vitro and in vivo has been imputed by functional studies and identification of tumor-acquired gene defects or alterations in its expression. To study the generality and mechanisms of p53 alteration in human cancer, we examined 241 tumors of several types for structural aberrations of the locus. Alterations of the gene or its RNA or protein...

Topics

Animals
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA, Neoplasm
Heterozygote
Homozygote
Humans
Mice
Mice, Nude
Mutation
Neoplasm Transplantation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins

Osteosarcoma

Phosphoproteins

Polymerase Chain Reaction

RNA, Neoplasm

Rhabdomyosarcoma

Source

Open in PubMed Open full text

Identifiers

PMID: 2143022
DOI: 10.1073/pnas.87.15.5863
PMCID: PMC54429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2143022-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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