Article
P53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines.
Medical and pediatric oncology - 1 Aug 2000
Taylor A C, Shu L, Danks M K, Poquette C A, Shetty S, Thayer M J, Houghton P J, Harris L C
Abstract excerpt
BACKGROUND: The p53 tumor suppressor gene is the most commonly mutated gene in human cancer, and mutations arise in a wide variety of tumor types. Wild-type p53 functions as a regulator of apoptosis, so mutations in the p53 gene are generally associated with aggressive tumors and a poor prognosis. PROCEDURE: We have investigated the p53 mutation and MDM2 amplification frequencies in biopsies from pediatric...
Topics
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
- Blotting, Southern
- Cell Line
- Child
- Child, Preschool
- Combined Modality Therapy
- Exons
- Gene Amplification
- Humans
- Infant
- Mutation
- Neoplasm Proteins