Article
Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.
Cancer - 1 Apr 2014
Hettmer Simone, Archer Natasha M, Somers Gino R, Novokmet Ana, Wagers Amy J, Diller Lisa, Rodriguez-Galindo Carlos, Teot Lisa A, Malkin David
Abstract excerpt
BACKGROUND: Rhabdomyosarcoma (RMS) represents a diverse category of myogenic malignancies with marked differences in molecular alterations and histology. This study examines the question if RMS predisposition due to germline TP53 mutations correlates with certain RMS histologies. METHODS: The histology of RMS tumors diagnosed in 8 consecutive children with TP53 germline mutations was reviewed retrospectively. In...
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