Article
Mutation analysis of p53 gene in childhood malignant solid tumors.
Journal of pediatric surgery - 1 Aug 1997
Kusafuka T, Fukuzawa M, Oue T, Komoto Y, Yoneda A, Okada A
Abstract excerpt
Alterations of the p53 gene have been extensively investigated in a wide variety of human malignancies. However, data on childhood malignant solid tumors are still limited. Mutations of the p53 gene on exons 5 through 8 were examined in 82 childhood malignant solid tumors by the polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) method, and the nature of these mutations was confirmed by...
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