Mutation analysis of p53 gene in childhood malignant solid tumors.

doi:10.1016/s0022-3468(97)90677-1

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Article

Mutation analysis of p53 gene in childhood malignant solid tumors.

Journal of pediatric surgery - 1 Aug 1997

Kusafuka T, Fukuzawa M, Oue T, Komoto Y, Yoneda A, Okada A

Abstract excerpt

Alterations of the p53 gene have been extensively investigated in a wide variety of human malignancies. However, data on childhood malignant solid tumors are still limited. Mutations of the p53 gene on exons 5 through 8 were examined in 82 childhood malignant solid tumors by the polymerase chain...

Topics

Child
Codon
Genes, p53
Hepatoblastoma
Humans
Kidney Neoplasms
Liver Neoplasms
Mutation
Neuroblastoma
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Rhabdomyosarcoma
Sequence Analysis, DNA
Wilms Tumor

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