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Article

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma.

1 Apr 1995

Abstract excerpt

We investigated the possibility that a proportion of children with sporadic rhabdomyosarcoma (RMS) carry constitutional mutations of the p53 tumor suppressor gene. 33 patients with sporadic RMS at two large outpatient pediatric oncology clinics submitted blood samples. Genomic DNA was extracted from peripheral blood leukocytes and PCR was used to amplify exons 2-11 of the p53 gene. Amplified genomic DNA was...

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Identifiers

PMID: 7706467
DOI: 10.1172/jci117834

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Source receipt: pubmed, retrieved 7 Sept 2026.

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