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Article

Novel mdm2 splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines.

Oncology research - 1 Jan 2001

Bartel F, Taylor A C, Taubert H, Harris L C

Abstract excerpt

Mdm2 is an oncogene that binds to and inactivates the tumor suppressor p53. However, the presence of oncogenic splice variants of mdm2 in human tumors that lack the p53 binding site has suggested a p53-independent transforming function for this protein. This report describes expression of 11 different mdm2 splice variants in pediatric rhabdomyosarcoma (RMS) cell lines and tumors at a frequency of 75% and 82%,...

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Source

Identifiers

PMID: 11939408
DOI: 10.3727/096504001108747459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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