Article
Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.
Cancer research - 15 Aug 2010
Xu Jianmin, Timares Laura, Heilpern Clay, Weng Zhiping, Li Changzhao, Xu Hui, Pressey Joseph G, Elmets Craig A, Kopelovich Levy, Athar Mohammad
Abstract excerpt
Rhabdomyosarcoma (RMS) is a common soft-tissue sarcoma of childhood in need of more effective therapeutic options. The expression of p53 in RMS is heterogeneous such that some tumors are wild-type whereas others are p53 mutant. The small molecule CP-31398 modulates both the wild-type and the mutant p53 proteins. Here, we show that CP-31398 blocks the growth of RMS cells that have either wild-type or mutant p53...
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