Article
Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.
PloS one - 1 Jan 2012
Alsina Fernando C, Irala Dolores, Fontanet Paula A, Hita Francisco J, Ledda Fernanda, Paratcha Gustavo
Abstract excerpt
The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression of Spry4 mRNA in response to NGF, indicating that Spry4 could modulate intracellular signaling pathways and biological processes induced by NGF and its receptor TrkA. In this work, we demonstrate...
Topics
- Animals
- COS Cells
- Cell Line, Tumor
- Extracellular Signal-Regulated MAP Kinases
- MAP Kinase Signaling System
- Mutation
- Nerve Growth Factor
- Nerve Tissue Proteins
- Neurons
- PC12 Cells
- RNA, Small Interfering
- Rats
- Rats, Sprague-Dawley