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Article

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.

PloS one - 1 Jan 2012

Alsina Fernando C, Irala Dolores, Fontanet Paula A, Hita Francisco J, Ledda Fernanda, Paratcha Gustavo

Abstract excerpt

The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression of Spry4 mRNA in response to NGF, indicating that Spry4 could modulate intracellular signaling pathways and biological processes induced by NGF and its receptor TrkA. In this work, we demonstrate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22384148
DOI: 10.1371/journal.pone.0032087
PMCID: PMC3285629

Genes

NGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.PMID 22384148Read ↗

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