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Article

Inhibition of activated Ras-induced neuronal differentiation of PC12 cells by the LIM domain of LIM-kinase 1.

Oncogene - 17 Apr 1997

Higuchi O, Amano T, Yang N, Mizuno K

Abstract excerpt

LIM-kinase 1 and 2 (LIMK1 and LIMK2) are members of a novel class of protein kinases with structures composed of two LIM motifs at the N-terminus and an unusual protein kinase domain at the C-terminus. The cellular functions of the LIMK family proteins have remained unknown. In the present study, we examined effects of LIMKs on neuronal differentiation of PC12 pheochromocytoma cells. Transient expression analyses...

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Source

Identifiers

PMID: 9150388
DOI: 10.1038/sj.onc.1201020

Genes

LIMK1
LIMK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Inhibition of activated Ras-induced neuronal differentiation of PC12 cells by the LIM domain of LIM-kinase 1.PMID 9150388Read ↗

Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation.Semantic proximity Read ↗

Roles of LIM kinases in central nervous system function and dysfunctionSemantic proximity Read ↗

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.Semantic proximity Read ↗

Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.Semantic proximity Read ↗

Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.Semantic proximity Read ↗

The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.Semantic proximity Read ↗

Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.Semantic proximity Read ↗

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.Semantic proximity Read ↗

Role for DLK1 in neuronal differentiation of mouse and human embryonic stem cellsSemantic proximity Read ↗

LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer.Semantic proximity Read ↗

Cytoplasmic localization of LIM-kinase 1 is directed by a short sequence within the PDZ domain.Semantic proximity Read ↗

Inhibition of neuronal phenotype by PTEN in PC12 cells.Semantic proximity Read ↗

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