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Article

The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells.

PloS one - 1 Jan 2014

Flowers Brittany M, Rusnak Lauren E, Wong Kristen E, Banks Dallas A, Munyikwa Michelle R, McFarland Alexander G, Hinton Shantá D

Abstract excerpt

The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation of the extracellular signaling related kinase (ERK) pathway is required. Here, we investigate the function of MK-STYX [MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein] in neuronal differentiation. MK-STYX is a member of the MAPK phosphatase (MKP)...

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Source

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Identifiers

PMID: 25479605
DOI: 10.1371/journal.pone.0114535
PMCID: PMC4257672

Genes

STYX
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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