Article
Amino acids important for ligand specificity of the human constitutive androstane receptor.
The Journal of biological chemistry - 18 Feb 2005
Jyrkkärinne Johanna, Windshügel Björn, Mäkinen Janne, Ylisirniö Markku, Peräkylä Mikael, Poso Antti, Sippl Wolfgang, Honkakoski Paavo
Abstract excerpt
The human constitutive androstane receptor (CAR, NR1I3) is an important ligand-activated regulator of oxidative and conjugative enzymes and transport proteins. Because of the lack of a crystal structure of the ligand-binding domain (LBD), wide species differences in ligand specificity and the scarcity of well characterized ligands, the factors that determine CAR ligand specificity are not clear. To address this...
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