Article
Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.
Molecular genetics and metabolism - 1 Jan 2000
Savkur Rajesh S, Wu Yifei, Bramlett Kelli S, Wang Minmin, Yao Sufang, Perkins Douglas, Totten Michelle, Searfoss George, Ryan Timothy P, Su Eric W, Burris Thomas P
Abstract excerpt
The human constitutive androstane receptor (hCAR; NR1I3) is a member of the nuclear receptor superfamily. The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes responsible for xenobiotic metab...
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