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Article

Pharmacogenetics of the constitutive androstane receptor.

Pharmacogenomics - 1 Jan 2008

Lamba Jatinder K

Abstract excerpt

The constitutive androstane receptor (CAR), a member of the NR1I group of nuclear hormone receptors, has been implicated in regulating the expression of genes that are critical in xenobiotic and endobiotic metabolism, uptake and elimination as well as genes involved in various other physiological processes. Hence, functional variation in CAR associated with its expression and/or activity can influence the...

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PMID: 18154449
DOI: 10.2217/14622416.9.1.71

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