Functional analysis of four naturally occurring variants of human constitutive androstane receptor.

doi:10.1016/j.ymgme.2005.05.011

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Article

Functional analysis of four naturally occurring variants of human constitutive androstane receptor.

Molecular genetics and metabolism - 1 Jan 2000

Ikeda Shinobu, Kurose Kouichi, Jinno Hideto, Sai Kimie, Ozawa Shogo, Hasegawa Ryuichi, Komamura Kazuo, Kotake Takeshi, Morishita Hideki, Kamakura Shiro, Kitakaze Masafumi, Tomoike Hitonobu, Tamura Tomohide, Yamamoto Noboru, Kunitoh Hideo, Yamada Yasuhide, Ohe Yuichiro, Shimada Yasuhiro, Shirao Kuniaki, Kubota Kaoru, Minami Hironobu, Ohtsu Atsushi, Yoshida Teruhiko, Saijo Nagahiro, Saito Yoshiro, Sawada Jun-ichi

Abstract excerpt

The human constitutive androstane receptor (CAR, NR1I3) is a member of the orphan nuclear receptor superfamily that plays an important role in the control of drug metabolism and disposition. In this study, we sequenced all the coding exons of the NR1I3 gene for 334 Japanese subjects. We identified three novel single nucleotide polymorphisms (SNPs) that induce non-synonymous alterations of amino acids (His246Arg,...

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PMID: 15990349
DOI: 10.1016/j.ymgme.2005.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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