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Article

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

Molecular pharmacology - 1 Nov 2012

Laurenzana Elizabeth M, Chen Tao, Kannuswamy Malavika, Sell Brian E, Strom Stephen C, Li Yong, Omiecinski Curtis J

Abstract excerpt

Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. The human constitutive androstane receptor (CAR; NR1I3) is expressed primarily in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and lipid homeostasis. In this report, DAX-1, a nuclear receptor family member with corepressor...

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Identifiers

PMID: 22896671
DOI: 10.1124/mol.112.080721
PMCID: PMC3477224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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