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Article

Signaling control of the constitutive androstane receptor (CAR)

28 Jan 2014

Abstract excerpt

The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes. Different from prototypical nuclear receptors, CAR can be activated by either direct ligand binding or ligand-independent (indirect) mechanisms both initiated with nuclear translocation of CAR from...

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PMID: 24474196
DOI: 10.1007/s13238-013-0013-0

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