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Minireview: Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges

28 Nov 2013

Abstract excerpt

Therapeutic targeting of nuclear receptors (NRs) is presently restricted due to 2 constraints: 1) a limited knowledge of the structural dynamics of intact receptor when complexed to DNA and coregulatory proteins; and 2) the inability to more selectively modulate NR actions at specific organ/gene targets. A major obstacle has been the current lack of understanding about the function and structure of the...

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PMID: 24284822
DOI: 10.1210/me.2013-1334

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